中文  |  ENGLISH

FACULTY

Position: HOME > PI



Suning Chen, Ph.D.

 

199 Ren'ai Rd. Suzhou, Jiangsu 215123, P.R.China

Institute of Blood and Marrow Transplantation (IBMT), Soochow University

Phone:

Fax:

E-mail: chensuning@suda.edu.cn

 

Education:

1992-1997, B.S., Medicine, Railway Medical College of Nanjing;

1997-2000, M.S., Hematology, Medical School of Southeast University;

2000-2003, Ph.D. Hematology, Soochow University;

 

Professional Experience:

2009-2011, The First Afflicated Hospital of Soochow University, Hematology department, Associate Chief Physician, Associate Professor;

2011-2014, The First Afflicated Hospital of Soochow University, Hematology department, Associate Chief Physician, Professor;

2014-present, The First Afflicated Hospital of Soochow University, Hematology department, Chief Physician, Professor;

 

Research:

Molecular diagnosis, discovery of new markers and pathogenesis of blood tumor.

 

Representative Publications

*corresponding author#co-first author)

1.       Ping N#, Sun A#, Song Y#, Wang Q#, Yin J, Cheng W, Xu Y, Wen L, Yao Hong, Ma L, Qiu H, Ruan C, Wu D*, Chen S*. Exome sequencing identifies highly recurrent somatic GATA2 and CEBPA mutations in acute erythroid leukemia. Leukemia (In press).

2.       Cheng J#, Guo S#, Chen S#, Mastriano SJ, Liu C, D'Alessio AC, Hysolli E, Guo Y, Yao H, Megyola CM, Li D, Liu J, Pan W, Roden CA, Zhou XL, Heydari K, Chen J, Park IH, Ding Y, Zhang Y*, Lu J*. An extensive network of TET2-targeting MicroRNAs regulates malignant hematopoiesis. Cell Rep. 2013;5(2):471-81.

3.       Yan L#, Ping N#, Zhu M#, Sun A, Xue Y, Ruan C, Drexler HG, Macleod RA, Wu D*, Chen S*. Clinical, immunophenotypic, cytogenetic, and molecular genetic features in 117 adult patients with mixed-phenotype acute leukemia defined by WHO-2008 classification. Haematologica. 2012 Nov;97(11):1708-12.

4.       Wang Q#, Qiu H, Jiang H, Wu L, Dong S, Pan J, Wang W, Ping N, Xia J, Sun A, Wu D, Xue Y, Drexler HG, Macleod RA, Chen S*. Mutations of PHF6 are associated with mutations of NOTCH1,  JAK1 and rearrangement of SET-NUP214 in T-cell acute lymphoblastic leukemia. Haematologica. 2011 Dec;96(12):1808-14.

5.       Chen S#, Nagel S, Schneider B, Kaufmann M, Meyer C, Zaborski M, Kees UR, Drexler HG, MacLeod RA*. Novel non-TCR chromosome translocations t(3;11)(q25;p13) and t(X;11)(q25;p13) activating LMO2 by juxtaposition with MBNL1 and STAG2. Leukemia. 2011 Oct;25(10):1632-5.

6.       Ping N#, Qiu H#, Wang Q, Dai H, Ruan C, Ehrentraut S, Drexler HG, MacLeod RA, Chen S*. Establishment and genetic characterization of a novel mixed-phenotype acute leukemia cell line with EP300-ZNF384 fusion. J Hematol Oncol. 2015 Aug 21;8(1):100. doi: 10.1186/s13045-015-0197-2.

7.       Wang Q#, Dong S, Yao H, Wen L, Qiu H, Qin L, Ma L, Chen S. ETV6 mutation in a cohort of 970 patients with hematologic malignancies. Haematologica. 2014 Oct;99(10):e176-8.

8.       Yao H#, Pan J, Wu C, Shen H, Xie J, Wang Q, Wen L, Wang Q, Ma L, Wu L, Ping N, Zhao Y, Sun A*, Chen S*. Transcriptome sequencing reveals CHD1 as a novel fusion partner of RUNX1 in acute myeloid leukemia with t(5;21)(q21;q22). Mol Cancer. 2015 Apr 11;14:81. doi: 10.1186/s12943-015-0353-x.

9.       Li M#, Wen L#, Cen J, Feng Y, Chen S*. JAK2V617F allele burden in patients with myeloproliferative neoplasms carrying Trisomy 9, and its relationship with clinical phenotypes. Int J Hematol. 2016 May;103(5):599-601.

10.   Shen H#, Chao H, Ding Z, Feng Y, Cen J, Pan J, He J, Zhou M, Chen Z, Chen S*. CALR and ASXL1 mutation analysis in 190 patients with essential thrombocythemia. Leuk Lymphoma. 2015 Mar;56(3):820-2.

11.   Wu L#, Xu Y#, Wang Q, Ruan C, Drexler HG, Wu D, MacLeod RA, Chen S*. High frequency of cryptic chromosomal rearrangements involving the LMO2 gene in T-cell acute lymphoblastic leukemia. Haematologica. 2015 Jun;100(6):e233-6.

12.   Xu Y#, Sun Y, Shen H, Ding L, Yang Z, Qiu H, Sun A, Chen S*, Wu D*. Allogeneic hematopoietic stem cell transplantation could improve survival of cytogenetically normal adult acute myeloid leukemia patients with DNMT3A mutations. Am J Hematol. 2015 Nov;90(11):992-7.

13.   Xie J#, Wang Q, Wang Q, Yao H, Wen L, Ma L, Wu D, Chen S*. High frequency of BTG1 deletions in patients with BCR-ABL1-positive acute leukemia. Cancer Genet. 2014 May;207(5):226-30.

14.   Wang W#, Wang Q, Tao T, Sun A, Ruan C, Chen S*. Identification of Two Novel β-Thalassemia Mutations (HBB: c.335-346del and HBB: c.108 C > G) in Han Chinese. Hemoglobin. 2015 Oct;39(5):359-61.

15.   Wen L#, Xia J#, Wang Q, Yao H, Xie J, Pan J, Xue Y, Wu D, Chen S*. Prognostic impact of residual normal metaphases in acute myeloid leukemia with t(8;21)(q22;q22). Int J Hematol. 2015 Aug;102(2):205-10.

16.   Ma X#, Wen L#, Wu L, Wang Q, Yao H, Wang Q, Ma L, Chen S*. Rare occurrence of a STAT5B N642H mutation in adult T-cell acute lymphoblastic leukemia. Cancer Genet. 2015 Jan-Feb;208(1-2):52-3.

17.   Ma W#, Liu J, Xie J, Zhang X, Zhou H, Yao H, Zhang W, Guo D, Zhu L, Xiao L, Wu D, Xu H, Chen S*, Zhao Y*. Modulating the Growth and Imatinib Sensitivity of Chronic Myeloid Leukemia Stem/Progenitor Cells with Pullulan/MicroRNA Nanoparticles In Vitro. J Biomed Nanotechnol. 2015 Nov;11(11):1961-74.

18.   Jiang H#, Qiu H#, Xue Y, Pan J, Wu Y, Zhang J, Zheng J, Wang Q, Liang J, Chen S*. Establishment and characterization of a novel acute myeloid leukemia cell line,  JIH-4,  carrying a t(16;21)(p11.2;q22) and expressing the FUS-ERG fusion. Cancer Genet. 2011 Apr;204(4):219-23.

19.   Zheng J#, Chen S#, Jiang L, You Y, Wu D, Zhou Y*. Functional genetic variations of cyclooxygenase-2 and susceptibility to acute myeloid leukemia in a Chinese population. Eur J Haematol. 2011 Dec;87(6):486-93.

20.   Chen H#, Pan J#, Yao L#, Wu L, Zhu J, Wang W, Liu C, Han Q, Du G, Cen J, Xue Y, Wu D, Sun M, Chen S*. Acute promyelocytic leukemia with a STAT5b-RARα fusion transcript defined by array-CGH, FISH, and RT-PCR. Cancer Genet. 2012 Jun;205(6):327-31.

21.   Jiang H#, Xue Y, Wang Q, Pan J, Wu Y, Zhang J, Bai S, Wang Q, He G, Sun A, Wu D, Chen S*.The utility of fluorescence in situ hybridization analysis in diagnosing myelodysplastic syndromes is limited to cases with karyotype failure. Leuk Res. 2012 Apr;36(4):448-52.

22.   Yin J#, Xu Y#, Pan J, Wu C, Wang Q, Yao H, Wen L, Tian X, Wu D, Sun A, Chen S*. Rare occurrence of the JAK1 mutation in acute promyelocytic leukemia patients. Acta Haematol. 2013;130(4):251-3.

23.   Wang X#, Dai H, Wang Q, Wang Q, Xu Y, Wang Y, Sun A, Ruan J, Chen S*, Wu D*. EZH2 mutations are related to low blast percentage in bone marrow and -7/del(7q) in de novo acute myeloid leukemia. PLoS One. 2013 Apr 17;8(4):e61341.

24.   Xu Y#, Yin J#, Pan J, Wu C, Wang Q, Yao H, Wu D, Chen S*, Sun A. A BCR-JAK2 fusion gene from ins(22;9)(q11;p13p24) in a patient with atypical chronic myeloid leukemia. Leuk Lymphoma. 2013 Oct;54(10):2322-4.

25.   Li X#, Yao H, Chen Z, Wang Q, Zhao Y, Chen S*. Somatic mutations of PHF6 in patients with chronic myeloid leukemia in blast crisis. Leuk Lymphoma. 2013 Mar;54(3):671-2.

26.   Ping N#, Wang Q, Wang Q, Dong S, Wu L, Xue Y, Ruan C, Wu D, Chen S*. Absence of BRAF V600E mutation in hematologic malignancies excluding hairy-cell leukemia. Leuk Lymphoma. 2012 Dec;53(12):2498-9.