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FACULTY

Position: HOME > PI



Haiyan Liu, Ph.D.

 

199 Ren'ai Rd. Suzhou, Jiangsu 215123, P.R.China

Institute of Blood and Marrow Transplantation (IBMT), Soochow University

Phone:

Fax:

E-mail: micliuh@nus.edu.sg

 

Education:

1989-1995, M.S., Medicine, Medical School of NanKai Universtiy;

1995-2000, Ph.D., Pathology, University of Tennessee Health Science Center

 

Professional Experience:

2009-2015, Institute of Biology and Medical Sciences of Soochow University, Distinguished Professor;

2015-present, Life Sciences Institute and Department of Microbiology and Immunology of National University of Singapore, Associate Professor

 

Research:

1. Tumor immunology

2. Transplantantion immunology

 

Representative Publications


*corresponding author#co-first author)

1.         Fen Liu, Fuyi Tong, Yan He, Haiyan Liu*   Detectable Expression of IL-35 inCD4+ T cells from Peripheral Blood of Chronic Hepatitis B Patients. Clinical Immunology. 2011 139:1-5

2.         Jun Ding, Yuzhen Gao, Rengyun Liu, Fei Xu, Haiyan Liu* Association of PTEN Polymorphisms with Susceptibility to Hepatocellular Carcinoma in Chinese Han Population. DNA and Cell Biology 2011 30(4):229-234

3.         Jun Ding, Yuzhen Gao, Yan He, Yifeng Zhou, Moli Huang, Haiyan Liu* Screening SNPs residing in the MicroRNA-Binding Sites of hepatocellular carcinoma related genes. Int. J. Data Mining and Bioinformatics. 2011 5(1):1-21

4.         Lan Jiang, Jianying Liang, Mingjun Jiang, Xiao Yu, Jian Zheng, Haiyan Liu, Depei Wu, Yifeng Zhou Functional Polymorphisms in the NBS1 gene and acute lymphoblastic leukemia susceptibility in a Chinese population. European Journal of Haematology. 2011 86(3):199-205

5.         Yan He, Fen Liu, Lurong Zhang, Yan Wu, Bo Hu, Yinsheng Zhang, Yunsen Li, Haiyan Liu* Growth Inhibition and Apoptosis Induced by Lupeol, a dietary triterpene, in Human Hepatocellular Carcinoma Cells. Biological & Pharmaceutical Bulletin 2011 34(4):517-522.

6.         Lei Zhou, Ru Cheng, Huiquan Tao, Shoubao Ma, Weiwei Guo, Fenghua Meng, Haiyan Liu, Zhuang Liu, and Zhiyuan Zhong.Endosomal pH-Activatable Poly(ethylene oxide)-graft-Doxorubicin Prodrugs: Synthesis, Drug Release, and Biodistribution in Tumor-Bearing Mice. Biomacromolecules 2011 12(5):1460-7

7.         Min Tao, Deliang Ma, Yan Li, Chong Zhou, Yan Li, Yinsheng Zhang, Weiming Duan, Xiujuan Xu, Rong Wang, Lingzhi Wu, Haiyan Liu*  Clinical Significance of Circulating Tumor Cells in Breast Cancer Patients. Breast Cancer Research and Treatment  2011 129(1):247-254

8.         Rui Yang, Fenghua Meng, Shoubao Ma, Fushi Huang, Haiyan Liu, and Zhiyuan Zhong Galactose-decorated cross-linked biodegradable poly(ethylene glycol)-b-poly(ε-caprolactone) block copolymer micelles for enhanced hepatoma-targeting delivery of paclitaxel. Biomacromolecules  2011 12(8):3047-55

9.         Fuxing Zhan, Wei Chen, Zhongjuan Wang, Wentao Lu, Ru Cheng, Chao Deng, Fenghua Meng, Haiyan Liu, and Zhiyuan Zhong Acid-activatable prodrug nanogels for efficient intracellular Doxorubicin release. Biomacromolecules. 2011 12(10):3612-20

10.     Ru Cheng ; Fenghua  Meng,  Shoubao Ma, Haifei  Xu, Haiyan Liu, Xiabin Jing, Zhiyuan Zhong  Reduction and temperature dual-responsive crosslinked polymersomes for targeted intracellular protein delivery Journal of Materials Chemistry, 2011 21(47), 19013-19020

11.     Qing Sun, Lixiang Zhao, Qingqing Song, Zheng Wang, Xusheng Qiu, Wenjun Zhang, Mingjun Zhao, Guo Zhao, Wenbo Liu, Haiyan Liu, Yunsen Li, Xiufan Liu. Hybrid- and complex-type N-glycans are not essential for Newcastle disease virus infection and fusion of host cells. Glycobiology. 2012 22(3):369-378

12.     Jinchao Zhang, Liangliang Wu, Fenghua Meng, Zhongjuan Wang, Chao Deng, Haiyan Liu, and Zhiyuan Zhong pH and Reduction Dual-Bioresponsive Polymersomes for Efficient Intracellular Protein Delivery. Langmuir. 2012 28(4):2056-65

13.     Lixiang Zhao and Haiyan Liu*  Newcastle Disease Virus: a Promising Agent for Tumor Immunotherapy.  Clinical and Experimental Pharmacology and Physiology 2012 39(8):725-30

14.     Shaoke Li, Fenghua Meng, Zhongjuan Wang, Yinan Zhong, Meng Zheng, Haiyan Liu, Zhiyuan Zhong Biodegradable polymersomes with an ionizable membrane: Facile preparation, superior protein loading, and endosomal pH-responsive protein release. Eur J Pharm Biopharm. 2012 82(1):103-11

15.     Zheng Wang , Lijun Wen, Xiao Ma, Zijun Chen, Yunhui Yu, Jian Zhu, Yanping Wang, Zhenming Liu, Haiyan Liu, Depei Wu, Dapeng Zhou, Yunsen Li  High expression of lactotriaosylceramide, a differentiation-associated glycosphingolipid, in the bone marrow of acute myeloid leukemia patients. Glycobiology. 2012 22(7):930-938

16.     Lurong Zhang, Guorong Jiang,  Fei Yao, Yan He,  Guoqiang Liang, Yinsheng Zhang, Bo Hu, Yan Wu, Yunsen Li,  Haiyan Liu* Growth inhibition and apoptosis induced by osthole, a natural coumarin, in hepatocellular carcinoma. PLoS ONE 2012 7(5):e37865

17.     Bo Hu, Guangming Bao, Yinsheng Zhang, Dandan Lin, Yan Wu, Depei Wu, Haiyan Liu* Donor NK Cells and IL-15 Promoted Engraftment in Nonmyeloablative Allogeneic Bone Marrow Transplantation. Journal of Immunology  2012 189(4):1661-70

18.     Yali Wu, Wei Chen, Fenghua Meng, Zhongjuan Wan, Ru Cheng, Chao Deng, Haiyan Liu, Zhiyuan Zhong Core-crosslinked pH-sensitive degradable micelles: A promising approach to resolve the extracellular stability versus intracellular drug release dilemma. J Control Release. 2012 164(3):338-45.

19.     Yong Liang and Haiyan Liu* Proteasome inhibition in transplantation-focusing on the experience with bortezomib. Current Pharmaceutical Design 2013 19(18):3299-304

20.     Yuejun Liu, Yifeng Cai, Lan Dai, Guanghua Chen, Xiao Ma, Ying Wang, Ting Xu, Song Jin, Xiaojin Wu, Huiying Qiu, Xiaowen Tang, Caixia Li, Aining Sun, Depei Wu, Haiyan Liu* The expression of Th17-associated cytokines in human acute graft-versus-host disease.  Biology of Blood and Marrow Transplantation 2013 19(10):1421-9.

21.     Fen Liu, Yan He, Yong Liang, Lijun Wen, Yongming Zhu, Yan Wu, Lixiang Zhao, Yunsen Li, Xinliang Mao, Haiyan Liu* PI3-kinase inhibition synergistically promoted the anti-tumor effect of lupeol in hepatocellular carcinoma. Cancer Cell International 2013 13(1):108

22.     Yong Liang, Shoubao Ma, Yanming Zhang, Ying Wang, Qiao Cheng, Yan Wu, Yue Jin, Donghui Zheng, Depei Wu, Haiyan Liu* IL-1β and TLR4 signaling are involved in the aggravated murine acute graft-versus-host disease caused by delayed bortezomib administration. Journal of Immunology 2014 192(3):1277-85.

23.     Shoubao Ma, Qiao Cheng, Yifeng Cai, Huanle Gong, Yan Wu, Xiao Yu, Liyun Shi, Depei Wu, Chen Dong, and Haiyan Liu* IL-17A produced by γδ T cells promotes tumor growth in Hepatocellular Carcinoma. Cancer Research 2014 74(7):1969-82.

24.     Lixiang Zhao, Yu Mei, Qing Sun, Linghua Guo, Yan Wu, Xiao Yu, Bo Hu, Xiufan Liu, and Haiyan Liu* Autologous Tumor Vaccine Modified with Recombinant New Castle Disease Virus Expressing IL-7 Promotes Anti-tumor Immune Response. Journal of Immunology 2014 193(2):735-745.

25.     Qiao Cheng, Shoubao Ma, Dandan Lin, Yu Mei, Huanle Gong, Lei Lei, Yuanyuan Chen, Ye Zhao, Bo Hu, Yan Wu, Xiao Yu, Lixiang Zhao, Haiyan Liu* S1P1 receptor-selective agonist CYM-5442 reduced the severity of acute GVHD by inhibiting macrophage recruitment. Cellular and Molecular Immunology 2014 Online.

26.     Yuejun Liu, Yan Wu, Ying Wang, Yifeng Cai, Bo Hu, Guangming Bao, Hongying Fang, Lixiang Zhao, Shoubao Ma, Qiao Cheng, Yuan Song, Yonghao Liu, Ziling Zhu, Huirong Chang, Xiao Yu , Aining Sun, Yi Zhang, Dario A. A. Vignali, Depei Wu, Haiyan Liu* IL-35 mitigates murine acute graft-versus-host disease with retention of graft-versus-leukemia effects. Leukemia 2015 (29):939–946.

27.     Dandan Lin, Lei Lei, Yinsheng Zhang, Bo Hu, Guangming Bao, Yonghao Liu, Yuan Song, Chunliang Liu, Yan Wu, Lixiang Zhao, Xiao Yu, and Haiyan Liu (2015) Secreted IL-1α promotes T-cell activation and expansion of CD11b(+) Gr1(+) cells in carbon tetrachloride-induced liver injury in mice. European Journal of Immunology 45(7):2084-98.

28.     Yuanyuan Chen, Ye Zhao, Qiao Cheng, Depei Wu, Haiyan Liu (2015) The role of intestinal microbiota in acute graft-versus-host disease. Journal of Immunology Research 2015:145859.

29.     Lei Zhao, Bo Hu, Yinsheng Zhang, Yuan Song, Dandan Lin, Yonghao Liu, Yu Mei, Dedy Sandikin, Weiping Sun, Min Zhuang, and Haiyan Liu. An activation-induced IL-15 isoform is a natural antagonist for IL-15 function. Scientific Reports. 2016 May 11;6:25822

30.     Dandan Lin, Lei Lei, Yonghao Liu, Yinsheng Zhang, Bo Hu, Guangming Bao, Yuan Song, Ziqi Jin, Chunliang Liu, Yu Mei, Dedy Sandikin, Yan Wu, Lixiang Zhao, Xiao Yu, and Haiyan Liu. Membrane IL1α Inhibits the Development of Hepatocellular Carcinoma via Promoting T- and NK-cell Activation. Cancer Research. 2016 Jun 1;76(11):3179-88.